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Research & Clinical Trials

Title
Author
YEAR
Name of Journal
Vol, Page

Unique multipotent cells in adult human mesenchymal cell populations.

Kuroda Y. et al.,
2010
Proc Natl Acad Sci USA
11;107(19):8639-4

Isolation, culture and evaluation of multilineage-differentiating stress-enduring (Muse) cells.

Kuroda Y. et al,.
2013
Nature Protocol
8(7):1391-415.

S1P-S1PR2 Axis Mediates Homing of Muse Cells Into Damaged Heart for Long-Lasting Tissue Repair and Functional Recovery After Acute Myocardial Infarction

Yamada Y., et al.,
2018
Cir Res
13;122(8):1069-1083

Phagocytosing differentiated cell-fragments is a novel mechanism for controlling somatic stem cell differentiation within a short time frame.

Wakao S. et al.
2022
Cell Mol Life Sci
6;79(11):542.

Tumor suppressor let-7 acts as a key regulator for pluripotency gene expression in Muse cells

Li G. et al.,
2024
Cell Mol Life Sci
23;81(1):54.  

The secretome of MUSE cells contains factors that may play a role in regulation of stemness, apoptosis and immunomodulation

Alessio N. et al.,
2017
Cell Cycle
16(1):33-44.

Why Do Muse Stem Cells Present an Enduring Stress Capacity? Hints from a Comparative Proteome Analysis.

Acar MB. Et al.,
2021
Int J Mol Sci.
22(4):2064.

Muse Cells Have Higher Stress Tolerance than Adipose Stem Cells due to the Overexpression of the CCNA2 Gene

Wang P. et al.,
2021
Stem Cells Dev.
30(21):1056-1069

Pluripotent Nontumorigenic Adipose Tissue-Derived Muse Cells have Immunomodulatory Capacity Mediated by Transforming Growth Factor-beta1.

Gimeno ML. et al.,
2017
Stem Cells Transl Med.
6(1):161-173. 

Endogenous reparative pluripotent Muse cells with a unique immune privilege system: Hint at a new strategy for controlling acute and chronic inflammation.

Kuroda Y. et al.,
2022
Front Pharmacol.
13:1027961.

Role of glycosphingolipid SSEA-3 and FGF2 in the stemness and lineage commitment of multilineage differentiating stress enduring (MUSE) cells.

Aprile D. et al.,
2023
Cell Prolif.
56(1):e13345

Unique multipotent cells in adult human mesenchymal cell populations.

Kuroda Y. et al.,
2010
Proc Natl Acad Sci USA
11;107(19):8639-4

Multilineage-differentiating stress-enduring (Muse) cells are a primary source of induced pluripotent stem cells in human fibroblasts.

Wakao S. et al.,
2011
Proc Natl Acad Sci USA
108(24):9875-80. 

Human adipose tissue possesses a unique population of pluripotent stem cells with nontumorigenic and low telomerase activities: potential implications in regenerative medicine.

Ogura F. et al.,
2014
Stem Cell Dev
23(7):717-28.

Pluripotent Nontumorigenic Adipose Tissue-Derived Muse Cells have Immunomodulatory Capacity Mediated by Transforming Growth Factor-beta1.

Gimeno ML. et al.,
2017
Stem Cells Transl Med.
6(1):161-173. 

Naïve pluripotent-like characteristics of non-tumorigenic Muse cells isolated from human amniotic membrane

Ogawa E. et al.,
2022
Sci Rep
2(1):17222.

Pluripotent Nontumorigenic Adipose Tissue-Derived Muse Cells have Immunomodulatory Capacity Mediated by Transforming Growth Factor-beta1.

Gimeno ML. et al.,
2017
Stem Cells Transl Med.
6(1):161-173. 

Human adipose tissue possesses a unique population of pluripotent stem cells with nontumorigenic and low telomerase activities: potential implications in regenerative medicine.

Ogura F. et al.,
2014
Stem Cell Dev
23(7):717-28.

Comparison of the Anti-Inflammatory Effects of Mouse Adipose- and Bone-Marrow-Derived Multilineage-Differentiating Stress-Enduring Cells in Acute-Phase Spinal Cord Injury.

Nagaoki T
2023
J Neurotrauma
40(23-24):2596-2609.

Quantitative Analysis of SSEA3+ Cells from Human Umbilical Cord after Magnetic Sorting.

Leng Z. et al.,
2019
Cell Transpl
28(7):907-923.

Naïve pluripotent-like characteristics of non-tumorigenic Muse cells isolated from human amniotic membrane

Ogawa E. et al.,
2022
Sci Rep
2(1):17222.

Human post-implantation blastocyst-like characteristics of Muse cells isolated from human umbilical cord - PubMed

Kushida Y. et al.,
2024
Cell Mol Life Sci
 doi: 10.1038/s41598-022-22282-1.

Functional melanocytes are readily reprogrammable from multilineage-differentiating stress-enduring (muse) cells, distinct stem cells in human fibroblasts.

Tsuchiyama K. et al.,
2013
J Invest Dermatol.
133(10):2425-2435.

The Potential of Muse Cells for Regenerative Medicine of Skin: Procedures to Reconstitute Skin with Muse Cell-Derived Keratinocytes, Fibroblasts, and Melanocytes.

Yamauchi T, et al.,
2017
J Invest Dermatol.
137(12):2639-2642.

A Novel Type of Stem Cells Double-Positive for SSEA-3 and CD45 in Human Peripheral Blood.

Sato T, et al.,
2020
Cell Transpl.
29:963689720923574

Mobilized Muse Cells After Acute Myocardial Infarction Predict Cardiac Function and Remodeling in the Chronic Phase.

Tanaka T, et al.,
2018
Cir J
;82(2):561-571. 

Mobilization of Pluripotent Multilineage-Differentiating Stress-Enduring Cells in Ischemic Stroke.

Hori E. et al.,
2016
J Stroke Cerebrovasc Dis.
25(6):1473-81.

Muse cells; Endogenous reparative pluripotent stem cells

Dezawa M. eds
2018
Springer Nature
‎

Endogenous reparative pluripotent Muse cells with a unique immune privilege system: Hint at a new strategy for controlling acute and chronic inflammation.

Kuroda Y. et al.,
2022
Front Pharmacol.
‎ 13:1027961.

Donor Muse Cell Treatment Without HLA-Matching Tests and Immunosuppressant Treatment

Minatoguchi S. et al.,
2024
Stem Cell Transl Med.
13(6):532-545.

Clinical development of MUSE cell treatment: The challenges.

Stolk J.(commentary)
2016
Cell Cycle. 2016 Dec;
15(23):3165-3166.

S1P-S1PR2 Axis Mediates Homing of Muse Cells Into Damaged Heart for Long-Lasting Tissue Repair and Functional Recovery After Acute Myocardial Infarction

Yamada Y., et al.,
2018
Cir Res
13;122(8):1069-1083

Human Muse cells reduce myocardial infarct size and improve cardiac function without causing arrythmias in a swine model of acute myocardial infarction.

Yamada Y. et al.,
2022
Plos One
17(3):e0265347

Promoting early neovascularization by allotransplanted adipose-derived Muse cells in an ovine model of acute myocardial infarction.

Castillo MG, 
2023
Plos One
18(1):e0277442. 

Mobilized Muse Cells After Acute Myocardial Infarction Predict Cardiac Function and Remodeling in the Chronic Phase.

Tanaka T, et al.,
2018
Cir J
;82(2):561-571. 

Mobilization of Pluripotent Multilineage-Differentiating Stress-Enduring Cells in Ischemic Stroke.

Hori E. et al.,
2016
J Stroke Cerebrovasc Dis.
25(6):1473-81.

Safety and Efficacy of Human Muse Cell-Based Product for Acute Myocardial Infarction in a First-in-Human Trial.

Noda T, et al.,
2020
Cir. J
84(7):1189-1192.

Accumulation of endogenous Muse cells in the myocardium and its pathophysiological role in patients with fulminant myocarditis.

Toyoda S. et al.,
2024
Clin Transl Sci.
17(11):e70067.

Transplantation of Unique Subpopulation of Fibroblasts, Muse Cells, Ameliorates Experimental Stroke Possibly via Robust Neuronal Differentiation.

Uchida H. et al.,
2016
Stem Cells
34(1):160-73.

Neuro-regeneration therapy using human Muse cells is highly effective in a mouse intracerebral hemorrhage model

Shimamura N. et al.,
2017
Exp Brain Res
235(2):565-572.

Human Muse Cells Reconstruct Neuronal Circuitry in Subacute Lacunar Stroke Model.

Uchida H. et al.,
2017
Stroke
48(2):428-435.

Intravenously Transplanted Human Multilineage-Differentiating Stress-Enduring Cells Afford Brain Repair in a Mouse Lacunar Stroke Model.

Abe T. et al.,
2020
Stroke
51(2):601-611.

Cell-Based Therapy for Stroke: Musing With Muse Cells.

Park YJ, et al.,
2020
Stroke
51(9):2854-2862. 

Randomized placebo-controlled trial of CL2020, an allogenic muse cell-based product, in subacute ischemic stroke.

Niizuma K. et al.,
2023
J Cereb Blood Flow Metab.
43(12):2029-2039.

Intravenous Administration of Human Muse Cells Ameliorates Deficits in a Rat Model of Subacute Spinal Cord Injury.

Takahashi Y. et al.,
2023
Int J Mol Sci.
24(19):14603.

Association of intravenous administration of human Muse cells with deficit amelioration in a rat model of spinal cord injury.

Kajitani T, et al.,
2021
J Neurosurg Spine.
34(4):648-655.

Human Muse cells-derived neural precursor cells as the novel seed cells for the repair of spinal cord injury.

Chen X. et al.,
2021
Biochem Biophys Res Commun.
568:103-109.

Comparison of the Anti-Inflammatory Effects of Mouse Adipose- and Bone-Marrow-Derived Multilineage-Differentiating Stress-Enduring Cells in Acute-Phase Spinal Cord Injury.

Nagaoki T
2023
J Neurotrauma
40(23-24):2596-2609.

Safety and feasibility of intravenous administration of a single dose of allogenic-Muse cells to treat human cervical traumatic spinal cord injury: a clinical trial.

Koda M. et al.,
2024
Stem Cell Res Ther.
15(1):259.

Therapeutic benefit of Muse cells in a mouse model of amyotrophic lateral sclerosis.

Yamashita T. et al.,
2020
Sci Rep
10(1):17102.

Safety and Clinical Effects of a Muse Cell-Based Product in Patients With Amyotrophic Lateral Sclerosis: Results of a Phase 2 Clinical Trial.

Yamashita T. et al.,
2023
Cell Transpl
32:9636897231214370.

Intravenously delivered multilineage-differentiating stress enduring cells dampen excessive glutamate metabolism and microglial activation in experimental perinatal hypoxic ischemic encephalopathy.

Suzuki T. et al.,
2021
J Cereb Blood Flow Metab.
41(7):1707-1720.

Systemic administration of clinical-grade multilineage-differentiating stress-enduring cells ameliorates hypoxic-ischemic brain injury in neonatal rats.

Ueda K. et al.,
2023
Sci Rep
13(1):14958.

Safety and tolerability of a Muse cell-based product in neonatal hypoxic-ischemic encephalopathy with therapeutic hypothermia (SHIELD trial).

Sato Y. et al.,
2024
Stem Cells Transl Med.
13(11):1053-1066.

Intravenous Injection of Muse Cells as a Potential Therapeutic Approach for Epidermolysis Bullosa.

Fujita Y. et al.,
2021
J Invest Dermatol.
141(1):198-202.e6.

Intravenous allogeneic multilineage-differentiating stress-enduring cells in adults with dystrophic epidermolysis bullosa: a phase 1/2 open-label study.

Fujita Y. et al.,
2021
J Eur Acad Dermatol Venereol.
35(8):e528-e531.

A Distinct Subpopulation of Bone Marrow Mesenchymal Stem Cells, Muse Cells, Directly Commit to the Replacement of Liver Components.

Katagiri H. et al.,
2016
Am J Transpl
16(2):468-83.

Muse Cells, Nontumorigenic Pluripotent-Like Stem Cells, Have Liver Regeneration Capacity Through Specific Homing and Cell Replacement in a Mouse Model of Liver Fibrosis.

Iseki M. et al.,
2017
Cell Transpl
26(5):821-840.

Protection of liver sinusoids by intravenous administration of human Muse cells in a rat extra-small partial liver transplantation model.

Shono Y. et al.,
2021
Am J Transpl
21(6):2025-2039. 

The evaluation of the safety and efficacy of intravenously administered allogeneic multilineage-differentiating stress-enduring cells in a swine hepatectomy model.

Iseki M. et al.,
2021
Surg Today.
51(4):634-650.

Mobilization of multilineage-differentiating stress-enduring cells into the peripheral blood in liver surgery.

Kikuchi K. et al.,
2022
Plos One
17(7):e0271698.

The hepatic sinusoid: The "muse" in small-for-size liver transplantation.

Hessheimer AJ. et al.,
2021
Am J Transpl
21(6):1998-1999.

Human Multilineage-differentiating Stress-Enduring Cells Exert Pleiotropic Effects to Ameliorate Acute Lung Ischemia-Reperfusion Injury in a Rat Model.

Yabuki H. et al.,
2018
Cell Transpl
27(6):979-993.

Human Muse cells isolated from preterm- and term-umbilical cord delivered therapeutic effects in rat bleomycin-induced lung injury model without immunosuppressant.

Win KHN. et al.,
2024
Stem Cell Res Ther.
15(1):147.

Beneficial Effects of Systemically Administered Human Muse Cells in Adriamycin Nephropathy.

Uchida N. et al.,
2017
J Am Soc Nephrol.
28(10):2946-2960

Intravenously injected human multilineage-differentiating stress-enduring cells selectively engraft into mouse aortic aneurysms and attenuate dilatation by differentiating into multiple cell types.

Hosoyama K. et al.,
2018
J Thorac Cardiovasc Surg.
155(6):2301-2313.e4.

Musing on cell therapy for aortic aneurysms.

Della Corte A. et al.,
2018
J Thorac Cardiovasc Surg.
155(6):2314-2315.

Intravenous administration of human Muse cells recovers blood flow in a mouse model of hindlimb ischemia

Hori Y. et al.,
2022
Front Cardiovasc Med.
:9:981088.

Intravenously injected human multilineage-differentiating stress-enduring cells selectively engraft into mouse aortic aneurysms and attenuate dilatation by differentiating into multiple cell types.

Takahashi M. et al.,
2024
Commun Med (Lond).
4(1):174.

Therapeutic Potential of Adipose-Derived SSEA-3-Positive Muse Cells for Treating Diabetic Skin Ulcers

Kinoshita K,
2015
Stem Cells Transl Med.
4(2):146-55. 

mmunomodulatory Properties and Potential Therapeutic Benefits of Muse Cells Administration in Diabetes.

Perone MJ. et al.,
2018
Adv Exp Med Biol.
1103:115-129.

Fetal Muse-based therapy prevents lethal radio-induced gastrointestinal syndrome by intestinal regeneration.

Dushime H. et al.,
2023
Stem Cell Res Ther.
14(1):201.

Stem Cell Therapy Using Bone Marrow-Derived Muse Cells Repairs Radiation-Induced Intestinal Injury Through Their Intestine-Homing via Sphingosine Monophosphate-Sphingosine Monophosphate Receptor 2 Interaction.

Miura T. et al.,
2024
Adv Radiat Oncol.
9(9):101565.

Intravenous injection of human multilineage-differentiating stress-enduring cells alleviates mouse severe acute pancreatitis without immunosuppressants.

Fukase M. et al.,
2022
Surg Today.
52(4):603-615.

Muse cell spheroids have therapeutic effect on corneal scarring wound in mice and tree shrews.

Guo Y. et al.,
2020
Sci Transl Med.
12(562):eaaw1120.

Multilineage-differentiating stress-enduring cells alleviate atopic dermatitis-associated behaviors in mice.

Fei W. et al.,
2021
Stem Cell Res Ther.
12(1):606.

Functional melanocytes are readily reprogrammable from multilineage-differentiating stress-enduring (muse) cells, distinct stem cells in human fibroblasts.

Tsuchiyama K. et al.,
2013
J Invest Dermatol.
133(10):2425-2435.

A MUSE for Skin Regeneration.

Hu MS. et al.
2017
J Invest Dermatol.
137(12):2471-2472.

Therapeutic Potential of Multilineage-Differentiating Stress-Enduring Cells for Osteochondral Repair in a Rat Model.

Mahmoud EE. et al.,
2017
Stem Cells Int.
;2017:8154569.

Effects of human Muse cells on bladder inflammation, overactivity, and nociception in a chemically induced Hunner-type interstitial cystitis-like rat model

Furuta A. et al.,
2022
Int Urogynecol J
33(5):1293-1301

Intravenously engrafted human multilineage-differentiating stress-enduring (Muse) cells rescue erectile function after rat cavernous nerve injury

Koyama J,
2024
BJU Int.
133(3):332-340.

Rescue from Stx2-Producing E. coli-Associated Encephalopathy by Intravenous Injection of Muse Cells in NOD-SCID Mice.

Ozuru R. et al.,
2020
Mol Ther.
28(1):100-118. 

Genetically Engineered Multilineage-Differentiating Stress-Enduring Cells as Cellular Vehicles against Malignant Gliomas

Yamasaki T. et al.,
2017
Mol Ther Oncolytics
6:45-56.

Macrophage- and pluripotent-like reparative Muse cells are unique endogenous stem cells distinct from other somatic stem cells

Dezawa
25
Front Bioeng Biotechnol
Mar 27:13:1553382

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